Grape Seed Extract: A Complete Guide

Published On 29 Jun 2019
Written by
Team Setu
Written by
Team Setu

Grape Seed Extract – What’s all the hype about?

Seedless grapes may be all the rage in your neighborhood fruit market. But these grape seeds that we so loathe, could just hold the cure for a lot of ailments. What makes these seeds so amazing, you ask? The answer lies in proanthocyanidins, a type of phenol which is an extremely rich anti-oxidant agent – and also the key ingredient in grape seed extract.1 the effectiveness of grape seed extract is also seen as an excellent source of flavonoids, Vitamin E, linoleic acid and oligomeric procyanidins. 2 Research suggests that the antioxidant power of proanthocyanidins and catkins are about 20 times more than vitamin E and about 50 times greater than vitamin C. 3

Benefits of grape seed extract is found in the flavonoids found in it and in also that they possess properties of protection against cardiac disease, neural disorders, antimicrobial disorders, and anti-aging. 4

Sufficient research-based evidence is available that shows us what is grape seed extract good for. It has amazing blood pressure balancing properties. The mechanism of action suggested is that the flavonoids in GSE cause relaxation of the arteries and blood vessels thereby reducing hypertension. In cases of chronic venous insufficiencies where there is painful dilatation of veins in the legs, GSE has shown to reduce the symptoms of the disease. A study conducted on 60 subjects with GSE and revealed that the group who received a dose of grape seed extract suffered from less edema and pain post-surgery in comparison to the placebo group. 5

Another study published in the Journal of Free Radical Biology and Medicine helped us understand the health benefits of grape seed extract. It concluded that proanthocyanidin extract, when applied to the wounds on the backs of mice, had quicker healing times. Thus it can be inferred that GSE has the potential to increase the wound healing capacity of the wound. 6

Another study conducted to find out the benefits of grape seed extract concluded that the GSE when coupled with adequate calcium intake in the diet, can aid in the bone formation and strengthening of bone and can also be used as an adjunctive in the treatment of bone disorders due to low calcium levels. 6

A grape seed extract has emerged as one of the most potent nutraceuticals for overall wellness. Various researches and studies have brought about a clear understanding of what is grape seed extract good for and as a result, They are now available in various forms commercially as a dietary supplement in capsules, tablets, and liquid extracts. Setu’s Pressure Pal contains the goodness of Grape Seed Extract along with other great ingredients like CoQ10 and Anthocyanins that help you regulate your blood pressure.

Learn more about Pressure Pal, here.


  1. Shi J, Yu J, Pohorly J, Kakuda Y. Polyphenolics in Grape Seeds—Biochemistry and Functionality. Journal of Medicinal Food. 2003;6(4):291-299. DOI:10.1089/109662003772519831.

2.El-Beshbishy H, Mohamadin A, Abdel-Naim A. In Vitro Evaluation of the Antioxidant Activities of Grape Seed (Vitis vinifera) Extract, Blackseed (Nigella sativa) Extract and Curcumin. Journal of Taibah University Medical Sciences. 2009;4(1):23-35. doi:10.1016/s1658-3612(09)70078-2

  1. Shi J, Yu J, Pohorly J, Kakuda Y. proanthocyanidin in Grape Seeds—Biochemistry and Functionality. Journal of Medicinal Food. 2003;6(4):291-299. doi:10.1089/109662003772519831.
  2. Recent Advances and Uses of Grape Flavonoids as Nutraceuticals. Vasil Georgiev,* Anthony Ananga, and Violeta Tsolova Nutrients. 2014 Jan; 6 (1): 391–415.
  3. Grape seed. University of Maryland Medical Center. 2016. Accessed June 7, 2017.

Grape Seed Extract: How Healthful Is It?

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